For Complete Freedom From Pain
D E S C R I P T I O N / M O D E O F A C T I O N
Tramadol is a centrally acting analgesic structurally related to opioid derivatives like codeine. Tramadol acts at both spinal and supraspinal areas. It acts by two mechanisms.
By inhibiting the neuronal uptake of serotonin and norepinephrine, it reduces pain
By binding to μ opioid receptors it reduces pain.
Thus the effect of tramadol is the sum of both the above actions.
Pharmacikinetics : Tramdol is rapidly and almost completely absorbed after oral administration .
Bioavailability : 75%
Plasma protien binding : 20%
Duration of action : 6 hours
Metabolised by liver and excreted by kidney. M1 metabolite is 6 times as potent as the parent drug. This enhances the duration action. Dose may need to be adjusted in renal / hepatic failure and in very old patients
Paracetamol is a time tested analgesic antipyretic. It has weak activity on prostaglandin synthatase in the peripheral inflamed tissue. However it equals the blocking effect of aspirin on this enzyme in the brain. Therefore paracetamol is a potent antipyretic and is equianalgesic with aspirin in therapeutic doses.
Clinical efficacy : Tramodol and paracetamol in combination is incresingly becoming popular for the treatment of moderate to severe pain. Besides providing good analgesic efficacy this combination improves exercise capability in such patients
C O M P O S I T I O N
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I N D I C AT I O N S
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D O S A G E
Moderate to Severa Pain: 1 – 2 Tablets 3 to 4 times a day.
S I D E E F F E C T S
Common side effects include nausea, vomiting, dry mouth, dizzinesss, headach and sedation.
C O N T R A I N D I C A T I O N S
Known hypersensitivity to any of the ingredients or excipients or opioids.
Acute intoxication with alcohol, hypnotics, opioids, psychoactive substances.
Concurrent intake of monoamine oxidase inhibitors (MAOIs)
Inadequately controlled epilepsy.
P R E S E N TAT I O N & PACK
Kamadol – P: 10 X 10’s Tablets in blister packs.
