The Bacterial Claw Against Microbes
D E S C R I P T I O N / M O D E O F A C T I O N
Verclav is a combination of Amoxicillin and clavulanic acid. Amoxicillin: This drug, penicillinase-susceptible semi-synethetic penicillin, is a close chemical and pharmacological relative of ampicillin. Aminopenicillins are bactericidal for both gram-positive and gram-negative bacteria. The meningococci and L. monocytogenes are sensitive to the drug. Most strains of Shigella are now resistant. Most strains of Pseudomonas, Klebsiella, Serratia Acinetobacter, and indole positive Proteus also are resistant to this group of penicillin. However, concurrent administration of a beta-lactamase inhibitor such as clavulanate or sulbactam markedly expands the spectrum of activity of these drugs.
Clavulanic acid has poor intrinsic antimicrobial action, (by itself it cannot kill the bacteria) but it is a ‘suicide’ inhibitor. It combines irreversibly with Beta lactamase enzyme rendering the enzyme inactive. This inactivated enzyme is unable to destroy Beta lactamase antibiotics (penicillins and cephalosporins). Thus a resistant organism becomes susceptible to the action of antibiotics.
C O M P O S I T I O N
I N D I C AT I O N S
D O S A G E
Adults- 250-500 mg every 8hr/ 500-750 mg every 12 hr
Children – 125-250 mg every 8 hr, if less than <40 kg: 20-40 mg/kg/day
S I D E E F F E C T S
GI Adverse effects- diarrhea, Candidiasis, antibiotic-associated colitis
Skin rash, (urticarial and erythematous) sometimes occurs.
Rarely erythema multiforme,
Stevens-Johnson syndrome, toxic epidermal necrolysis, bullous exfoliative dermatitis and acute generalised exanthematous opustulosis
C O N T R A I N D I C A T I O N S
Attention should be paid to possible cross-sensitivity with other beta-lactam antibiotics, e.g. Cephalosporins.
A previous history of Clavulanate Potassium and Amoxycillin Injection or Penicillin associated jaundice/hepatic dysfunction
P R E S E N TAT I O N & PACK
Verclav 625 mgTab – 10×10 Alu Alu pack
Verclav Dry Syrup – 30ml with Carton
Verclav inj – 1.2gm in Mono Carton