The quicker, safer pain relief in migraine attack
D E S C R I P T I O N / M O D E O F A C T I O N
Grenil is a combination of Domperidone and Paracetamol. Domperidone is a benzimidazole derivative. It is a selective antagonist of the peripheral dopamine D 2 receptors in stomach and acts on chemoreceptor triggerzone (CTZ). After oral administration, Domperidone is absorbed rapidly and almost completely. The peak plasma concentrations reached within 30 minutes are 23 ng / ml after a 10 mg dose and 80 – 102 ng / ml after a 60 mg dose, Domperidone is bound to plasma proteins (91% – 93%). Roughly 1/3 rd of the administered dose is eliminated through the kidney within the first 24 hours. About 10% of the drug is excreted unchanged in faeces. The elimination half-life of Domperidone is 1.5 hours. It has antiemetic and prokinetic properties. Domperidone has no cholinomimetic (acetyl choline like) action at the peripheral muscarinic receptors. Entry of Domperidone into the CNS is poor. Domperidone constricts the lower oesophageal sphincter and relaxes the pyloric sphincter, thereby abolishes nausea, vomiting and alleviates symptoms of postprandial dyspepsia.
Paracetamol is N-acetyl-para aminophenol, has an effective analgesic and antipyretic properties. Paracetamol is rapidly and almost completely absorbed from the gastrointestinal tract. The plasma concentration reaches a peak in 30 to 60 minutes and the half-life in plasma is about 2 hours. Paracetamol is relatively uniformly distributed throughout the body. Plasma protein binding is around 20% to 50%. After therapeutic doses, 90% to 100% of the drug may be recovered in the urine within the first day, primarily after hepatic metabolism.
C O M P O S I T I O N
I N D I C AT I O N S
D O S A G E
The recommended dosage is as follows :
15 Years & above : 1-2 tablets at the onset of attack, subsequently one tablet every 4 hours, if needed, not exceeding 4 tablets per day.
12-15 Years : 1 tablet at the onset of attack, maximum 3 tablets in 24 hours.
S I D E E F F E C T S
Very rarely allergic reactions and skin rashes may occur. In a few isolated cases, Paracetamol may cause meutropenia, thrombocytopenias and pancytopenia. In adults, hepatotoxicity may occur after ingestion of a single dose of 10 to 15 gm Paracetamol, which may cause a potentially fatal hepatic necrosis. Over dosage may be treated with N-acetyl cysteine – 5% solution orally. Domperidone has been well tolerated in most cases. Occasional minor effects include dry mouth, thirst, headache, diarrhoea, nervousness & transient rash. Extra-pyramidal side effects are rare with Domperidone.
P R E S E N TAT I O N & PACK
Tablet : Strips of 10 X 10’s in Blister pack
Susp : Bottle of 60 ml