For a comprehensive relief in Migraine management
D E S C R I P T I O N / M O D E O F A C T I O N
Flunarizine is a selective calcium antagonist. Prevents cellular calcium overload by reducing excessive transmembrane calcium influx. Its mode of action in migraine is unclear, possible mechanisms are inhibition of vasospasm induced by mediators such as serotonin & prostaglandins, inhibition of cellular hypoxia, & improved blood viscosity & erythrocyte deformability. Flunarizine by blocking calcium channels of vascular smooth muscels of the cranial arteries inhibits vasoconstriction of those arteries. This in turn avoids smooth muscle fatigue & subsequent vasodilatation.
Flunarizine is well absorbed from the gut, peak plasma levels are reached within 2-4hrs and reaching steady state at 5-6 weeks. Under goes extensive hepatic metabolism, excreted through faeces via bile. The terminal elimination half life is about 18 days. Plasma protein binding is 99%. Flunarizine crosses blood brain barrier.
C O M P O S I T I O N
I N D I C AT I O N S
|Grenil F is recommended in :
|Prophylaxis of migraine
|Prophylaxis of vertigo & vestibular disorders
|Prophylaxis of pheripheral & cerebrovascular disorders
D O S A G E
The recommended dosage is as follows :
Adults : 10mg once a day at bedtime.
7-15 Years / <40 kg : 5mg initially & 10mg later, depending on response.
S I D E E F F E C T S
Sedation, fatigue, weight gain / increased appetite
On chronic treatment – Depression (female patients with the history of depressive illness)
Extrapyramidal symptoms (bradykinesia, rigidity , akathisia, orofacial dyskinesia, tremor)
Infrequently reported adverse reaction : heartburn, nausea, gastralgia, insomnia, anxiety, galactorrhoea, dry mouth, muscle ache
P R E S E N TAT I O N & PACK
Grenil – F 5 mg : Strips of 10 X 10’s in Blister pack
Grenil – F 10 mg : Strips of 10 X 10’s in Blister pack