THE PROVEN POWER OF ANTIMICROBIAL AGENT / SYNERGY
D E S C R I P T I O N / M O D E O F A C T I O N
CERPAR – SB* is a combination of Cefoperazone sodium and Sulbactam sodium . It exhibits a broad spectrum of antimicrobial activity on Gram negative, Gram positive and Anaerobic organisms. They are very much useful in emergency cases where other antibiotics are found ineffective because of their high degree of reliability with wider spectrum of activity. Cefpar – SB exhibits antimicrobial synergy and has lower MIC than Cefoperazone alone. Also Sublactam enhances the antibacterial potency of Cefoperazone in Cefpar – SB.
C O M P O S I T I O N
|Each vial CEFPAR SB-1 G INJ (dry powder for injection) contains||Cefoperazone sodium USP 500mg<||Sulbactam sodium USP 500mg|
|Each vial CEFPAR SB-1.5 G INJ (dry powder for injection) contains :||Cefoperazone sodium USP 1gm||Sulbactam sodium USP 0.5 gm|
I N D I C AT I O N S
Monotherapy : They are indicated for the treatment of the following infections when caused by susceptible organisms – Respiratory tract infections (Upper and Lower), Urinary tract infections (Upper and Lower), Peritonitis, Cholecystitis, Cholangitis, and other Intra abdominal infections, Septicemia, Meningitis, Pelvic inflammatory disease, Endometritis, Gonorrhea and other infections of the Genital tract, Skin and soft tissue infections, Bone and joint infections.
Combination therapy : Because of the broad spectrum of activity of Cefpar – SB, most infections cn be treated adequately with this alone. However, it may be used concomtantly with other antibiotics if such combinations are indicated. If an aminoglycoside is used, renal function shoud be monitored during the course of therapy.
D O S A G E
1g or 2g every 12 hours in adults and 50 to 200mg / kg daily in children. For neonates aged less than 8 days, the drug shoud not be given more frequently than 12 hourly. The daily dose may be increased to 8g or 300 mg/kg/day in severe infections.
2g to 4g every 12 hours in adults 40 to 80mg / kg daily in children every 6 to 12 hours in equally divided doses. The recommended maximum daily dosage of sulbactam is 4g. For neonates in the first week of life, the drug should be given every 12 hours. The maximum daily dosage of sulbasctam in paediatrics should not exceed 80mg/kg/day. If more than 80mg/kg/day of cefoperazone activity are necessary, additional cefoperazone should be administered seperately.
S I D E E F F E C T S
Contraindications: Known hypersensitivity to cephalosporin class of antibiotics.
Warning: CEFPAR – SB should be administered with caution to any patient who is penicillin sensitive or has demonstrated any other form of allergy, particularly to drugs.
The adverse reactions include allergic reactions, reversible neutropenia, positive direct Coomb’s test, anemia and reduced hematocrit, transient eosinophilia and hypoprothrombinemia have been reported. Transient elevation of SGOT, SGPT, and alkaline phosphatase may occur. Loose stools or diarrhea of mild to moderate severity may occur and is reversible when therapy is terminated. Phlebitis at the site of infusion or transient pain on intramuscular administration may occur in some patients.
P R E S E N TAT I O N & PACK
CEFPAR SB-1 G INJ and CEFPAR SB-1.5 G INJ are presented in vials with unit pack